Monday, May 27, 2013

Nadal successfully begins bid for 8th French title

PARIS (AP) ? Rafael Nadal hopped, spun and threw an overhand punch toward his friends and family, stirring memories of past celebrations on his favorite stage.

After more than 90 minutes of tense tennis, Nadal had finally won a set, leaving him only 20 sets from another French Open championship.

The Spaniard survived an early scare Monday and successfully began his bid for an eighth title at Roland Garros by rallying past Daniel Brands of Germany, 4-6, 7-6 (4), 6-4, 6-3.

Nadal, who had lost only 14 sets in 53 previous matches at the French Open, fell behind when he was broken in the ninth game and was on the verge of digging a deeper hole in the red clay. He trailed 3-0 in the tiebreaker, then summoned his best shot-making to salvage the set and soon was in control against the dangerous Brands.

"He was playing unbelievable," Nadal said. "He was trying to hit every ball as hard as he can. Sometimes you feel you are not hitting a bad shot, and every time comes back a bomb. So I am very happy to be through, seriously."

Nadal, who won a record seventh French Open title last year, improved to 53-1 at Roland Garros. He's 37-2 since returning in February after a seven-month layoff because of a left knee injury, reaching the finals at all eight tournaments he played and winning six.

Defending women's champion Maria Sharapova needed only 54 minutes to advance, beating Hsieh Su-wei 6-2, 6-1. The No. 2-seeded Sharapova lost eight points in eight service games.

While Nadal took center stage, U.S. women fanned out to remote courts and quietly went 6-1. That included victories by Madison Keys, who won her Roland Garros debut, and by Melanie Oudin, who ousted No. 28 Tamira Paszek 6-4, 6-3. No. 17 Sloane Stephens, who reached the fourth round last year, beat Karin Knapp 6-2, 7-5.

American Ryan Harrison won a match at Roland Garros for the first time in three tries, beating Andrey Kuznetsov 6-3, 6-4, 7-6 (4). Harrison next plays fellow American and good friend John Isner, who improved to 4-4 at Roland Garros by beating Carlos Berlocq 6-3, 6-4, 6-4.

Li Na, the 2011 women's champion, beat nemesis Anabel Medina Garrigues in her opening match, 6-3, 6-4. Agnieszka Radwanska, last year's runner-up at Wimbledon, defeated Shahar Peer 6-1, 6-1.

The 6-foot-5 Brands, ranked 59th, came into his match against Nadal with an 0-4 career record at Roland Garros. But he gained a foothold with his big forehand and serves of up to 134 mph, while Nadal's feared groundstrokes lacked their normal depth and force at the outset.

The capacity crowd on center court sensed a possible upset and began rooting for Brands. But he gave Nadal an opening in the tiebreaker, blowing an easy backhand approach to make it 3-all.

"I was too sure to win the point and lost a little bit of concentration," Brands said. "That shouldn't happen against him."

From there the match quickly turned. On set point Nadal stretched to crack a backhand return into the corner for a winner, sparking his first celebration of the day.

"Winning the tiebreak, well, it was just like some oxygen," Nadal said. "I could finally breathe."

He earned his first service break of the match in the third set and held the rest of the way, serving better once he had the lead.

Seeded third but a heavy favorite, Nadal won his 16th consecutive match, and he improved to 34-0 in the first round at Grand Slams. He's trying to become the first man to win eight titles at the same major event.

Li, seeded No. 6, entered her match against Medina Garrigues with an 0-3 record on clay versus the Spaniard, but raced to a 4-0 lead after 20 minutes and broke serve six times.

Former top-ranked player Caroline Wozniacki of Denmark ended a five-match losing streak by defeating Laura Robson 6-3, 6-2.

No. 4 Radwanska needed less than hour to advance. It was her first match since withdrawing before last week's Brussels tournament with a recurrence of the right shoulder injury that has bothered her the past couple of years.

"I decided to have a week of rest and just practice," she said. "I think it was a good move."

She'll next play American Mallory Burdette, who won in her Roland Garros debut Sunday. Radwanska was asked what she knew about her second-round opponent.

"To be honest, not much. Nothing at all, actually," she said with a smile. "I might Google her."

The search for the next generation of U.S. stars has been ongoing, which made Monday's success notable. Keys beat Misaki Doi 6-3, 6-2; Vania King defeated Alexandra Cadantu 7-6 (3), 6-1; Bethanie Mattek-Sands eliminated Lourdes Dominguez Lino 6-4, 6-1; and No. 29 Varvara Lepchenko beat Mirjana Lucic-Baroni 6-1, 6-2.

"It's funny, because a couple of years ago, everyone was asking me: Where is women's tennis?" Mattek-Sands said. "Here we are now."

American Christina McHale lost to Jana Cepelova of Slovakia 7-6 (3), 2-6, 6-4.

On the men's side, Michael Russell of the United States retired with a left hamstring injury trailing Martin Klizan 3-6, 6-3, 6-1. Klizan plays Nadal in the second round.

Wild card Gael Monfils of France thrilled a partisan center court crowd by upsetting No. 5 Tomas Berdych in a match that ended at twilight, 7-6 (8), 6-4, 6-7 (3), 6-7 (4), 7-5. Nick Kyrgios of Australia, at 18 the youngest player in the men's draw, made a successful Grand Slam debut by beating 34-year-old Radek Stepanek 7-6 (4), 7-6 (8), 7-6 (11).

Source: http://news.yahoo.com/nadal-successfully-begins-bid-8th-french-title-142807997.html

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How an Affordable And Trusted Internet Hosting Solution Can ...

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Sunday, May 26, 2013

A list of previous Palme d'Or winners at Cannes

(AP) ? For 66 years, the Cannes Film Festival's highest prize, the Palme d'Or, has been one of the most prestigious in movies. Winners have ranged from classic American films (Martin Scorsese's "Taxi Driver," Francis Ford Coppola's "The Conversation") to European classics (Federico Fellini's "La Dolce Vita").

Ahead of Sunday's presentation of this year's Palme d'Or, here are the last 20 years of Cannes' Palme winners:

2012: "Amour," Michael Haneke

2011: "The Tree of Life," Terrence Malick

2010: "Uncle Boonmee Who Can Recall His Past Lives," Apichatpong Weerasethakul

2009: "The White Ribbon," Michael Haneke

2008: "The Class," Laurent Cantet

2007: "4 Months, 3 Weeks and 2 Days," Cristian Mungiu

2006: "The Wind That Shakes The Barley," Ken Loach

2005: "L'Enfant," Jean-Pierre Dardenne

2004: "Fahrenheit 9/11," Michael Moore

2003: "Elephant," Gus Van Sant

2002: "The Pianist," Roman Polanski

2001: "La Stanza del Figlio," Nanni Moretti

2000: "Dancer in the Dark," Lars Von Trier

1999: "Rosetta," Jean-Pierre and Luc Dardenne

1998: "Eternity and a Day," Theo Angelopoulos

1997: "The Eel," Shohei Imamura; and "Taste of Cherry," Abbas Kiarostami

1996: "Secrets & Lies," Mike Leigh

1995: "Underground," Emir Kusturica

1994: "Pulp Fiction," Quentin Tarantino

1993: "Farewell My Concubine," Kaige Chen; and "The Piano," Jane Campion

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/4e67281c3f754d0696fbfdee0f3f1469/Article_2013-05-25-EU-France-Cannes-Palme-List/id-3fbd98c0720b4392aa9d3758d5578e70

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Manufacturing Execution System (MES) Business Specialist Job

Manufacturing Execution System (MES) Business Specialist-ENG002488

Description

Merck is a global health care leader with a diversified portfolio of prescription medicines, vaccines and consumer health products, as well as animal health products. Today, we are building a new kind of healthcare company ? one that is ready to help create a healthier future for all of us.

Our ability to excel depends on the integrity, knowledge, imagination, skill, diversity and teamwork of people like you. To this end, we strive to create an environment of mutual respect, encouragement and teamwork. As part of our global team, you?ll have the opportunity to collaborate with talented and dedicated colleagues while developing and expanding your career.

Position Overview

The Manufacturing Execution System (MES) Business Specialist position is at the Maurice R. Hilleman Center for Vaccine Manufacturing which is located in northern Durham, North Carolina. This state of the art facility, started in 2004, is manufacturing Merk's lifesaving vaccines. Due to the importance of this facility in Merck?s Vaccine Manufacturing Supply Chain, the facility has seen rapid growth in production volumes and new employees over the last several years; currently Durham employs 1,000+ people. The successful MES Business Specialist candidate will have the opportunity to work in a dynamic and growing facility, and influence and ensure that our Vaccine products are available to customers throughout the world.

Supporting the world market will occur through ensuring the MES meets ongoing and future manufacturing requirements, assures its configuration is aligned with regulatory requirements, maximizes business benefits, and aligns it with Merck business process and technical standards. The Business Specialist is responsible for supporting MES implementations across the full systems lifecycle, from identifying the business and technical needs of users, determining appropriate implementation of the technology, executing implementation, and maintaining ongoing operations. The Business Specialist will have regular direct interaction with the MES users, ERP and Process Automation experts, and interface with Merck's MES Center of Excellence.

This specific role will be based at the Durham North Carolina manufacturing facility.

The Business Specialist is responsible for activities that include the following:

- Gain detailed knowledge of Werum's PAS-X MES application to enable production execution, including interfaces for ERP and DCS.
- Partner with site users and project teams to meet their needs through MES configuration. This includes active participation in the configuration of MES, then hands-on shop floor training and implementation which will require periodic shift and weekend support.
- Maintain MES as it relates to PAS-X system configuration, SLC, validation development/execution, hardware, software environments, SOPs and business processes.
- Collaborate in a network with other MES Subject Matter Experts to ensure that best practices are shared and resolve MES related investigations. Where required, participate in MES user groups within Merck to continuously improve the application and associated use practices.
- Actively participate in the refinement of PAS-X end-user training requirements they relate to configuration standards and operational activities.

Qualifications

Education:

- BS in Engineering, Computer Science, or other technical degree.

Required:

- Minimum of 4 years of experience front line supervision, process development, and/or process automation/IT support within the Pharmaceutical/Biopharmaceutical manufacturing business.
- Proven skills with integrated Manufacturing Execution Systems.
- Proven change management skills implemented at a manufacturing site level are essential.
- Excellent understanding of cGMP, and Process Automation System Life Cycle methodologies.
- Excellent written and oral communication skills.
- Excellent facilitation, problem solving, and decision making skills.

Preferred:

- Master Batch Record configuration experience using Werum's MES, PAS-X.
- SAP configuration experience for Production Execution.
- Distributed Control System, especially Emerson's DeltaV, coding experience for Process Automation.

Our employees are the key to our company?s success. We demonstrate our commitment to our employees by offering a competitive and valuable rewards program. Merck?s benefits are designed to support the wide range of goals, needs and lifestyles of our employees, and many of the people that matter the most in their lives.

Search Firm Representatives - Please read carefully:

Merck is not accepting unsolicited assistance from search firms for this employment opportunity. Please, no phone calls or emails. All resumes ted by search firms to any employee at Merck via-email, the Internet or in any form and/or method without a valid written search agreement in place for this position will be deemed the sole property of Merck. No fee will be paid in the event the candidate is hired by Merck as a result of the referral or through other means.

Merck is an equal opportunity employer, M/F/D/V ? proudly embracing diversity in all of its manifestations.
Former Military, Transitioning Service Members, National Guard & Reserves - We value your past and present service.

Job: Engineering Generic

Job Title: Spclst, Engineering

Primary Location: NA-US-NC-Durham

Employee Status: Regular

Number of Openings: 1


Nearest Major Market: Durham
Nearest Secondary Market: Raleigh
Job Segments: Engineer, Change Management, Industrial, Manufacturing, ERP, Engineering, Management, Technology

Source: http://jobs.merck.com/job/Durham-Manufacturing-Execution-System-(MES)-Business-Specialist-Job-NC-27701/2618703/?utm_source=J2WRSS&utm_medium=rss&utm_campaign=J2W_RSS

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First drug to significantly improve heart failure mortality in over a decade

May 25, 2013 ? Coenzyme Q10 decreases all cause mortality by half, according to the results of a multicentre randomised double blind trial presented today at Heart Failure 2013 congress. It is the first drug to improve heart failure mortality in over a decade and should be added to standard treatment, according to lead author Professor Svend Aage Mortensen (Copenhagen, Denmark).

Heart Failure 2013 is being held from 25-28 May in Lisbon, Portugal. It is the main annual meeting of the Heart Failure Association of the European Society of Cardiology (1).

Coenzyme Q10 (CoQ10) occurs naturally in the body and is essential to survival. CoQ10 works as an electron carrier in the mitochondria, the powerhouse of the cells, to produce energy and is also a powerful antioxidant. It is the only antioxidant that humans synthesise in the body.

CoQ10 levels are decreased in the heart muscle of patients with heart failure, with the deficiency becoming more pronounced as heart failure severity worsens. Statins are used to treat many patients with heart failure because they block the synthesis of cholesterol, but these drugs also block the synthesis of CoQ10, which further decreases levels in the body.

Double blind controlled trials have shown that CoQ10 improves symptoms, functional capacity and quality of life in patients with heart failure with no side effects. But until now, no trials have been statistically powered to address effects on survival.

The Q-SYMBIO study (2) randomised 420 patients with severe heart failure (New York Heart Association (NYHA) Class III or IV) to CoQ10 or placebo and followed them for 2 years. The primary endpoint was time to first major adverse cardiovascular event (MACE) which included unplanned hospitalisation due to worsening of heart failure, cardiovascular death, urgent cardiac transplantation and mechanical circulatory support. Participating centres were in Denmark, Sweden, Austria, Slovakia, Poland, Hungary, India, Malaysia and Australia.

CoQ10 halved the risk of MACE, with 29 (14%) patients in the CoQ10 group reaching the primary endpoint compared to 55 (25%) patients in the placebo group (hazard ratio=2; p=0.003). CoQ10 also halved the risk of dying from all causes, which occurred in 18 (9%) patients in the CoQ10 group compared to 36 (17%) patients in the placebo group (hazard ratio=2.1; p=0.01).

CoQ10 treated patients had significantly lower cardiovascular mortality (p=0,02) and lower occurrence of hospitalisations for heart failure (p=0.05). There were fewer adverse events in the CoQ10 group compared to the placebo group (p=0.073).

Professor Mortensen said: "CoQ10 is the first medication to improve survival in chronic heart failure since ACE inhibitors and beta blockers more than a decade ago and should be added to standard heart failure therapy."

He added: "Other heart failure medications block rather than enhance cellular processes and may have side effects. Supplementation with CoQ10, which is a natural and safe substance, corrects a deficiency in the body and blocks the vicious metabolic cycle in chronic heart failure called the energy starved heart."

CoQ10 is present in food, including red meat, plants and fish, but levels are insufficient to impact on heart failure. CoQ10 is also sold over the counter as a food supplement but Professor Mortensen said: "Food supplements can influence the effect of other medications including anticoagulants and patients should seek advice from their doctor before taking them."

Patients with ischaemic heart disease who use statins could also benefit from CoQ10 supplementation. Professor Mortensen said: "We have no controlled trials demonstrating that statin therapy plus CoQ10 improves mortality more than statins alone. But statins reduce CoQ10, and circulating CoQ10 prevents the oxidation of LDL effectively, so I think ischaemic patients should supplement statin therapy with CoQ10."

References: 1. Heart Failure Congress 2013 http://www.escardio.org/congresses/hf2013/Pages/welcome.aspx?hit=nav 2. SA Mortensen, A Kumar, P Dolliner, et al. The effect of coenzyme Q10 on morbidity and mortality in chronic heart failure. Results from the Q-SYMBIO study. Presented at Heart Failure Congress 2013 Final Programme Number 440. The full title of the Q-SYMBIO study is: "Coenzyme Q10 as adjunctive treatment of chronic heart failure: a randomised double blind multicentre trial with focus on changes in symptoms, biomarker status with BNP and long term outcome"?

Source: http://feeds.sciencedaily.com/~r/sciencedaily/most_popular/~3/d3uGwvq-8wM/130525143852.htm

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BYU knocks out Gonzaga at WCC baseball tourney - Spokesman ...

STOCKTON, Calif. ? The West Coast Conference regular-season champion Gonzaga Bulldogs in all likelihood saw their baseball season come to an early end as they lost their second straight game in the conference tournament on Friday?afternoon.

The top-seeded Bulldogs (32-21-1) were eliminated after falling 8-1 to No. 3 seed Brigham Young (32-20) at Banner Island?Ballpark.

With their seventh consecutive loss and an unimpressive RPI, the Bulldogs are not considered a probable candidate for an at-large NCAA tournament?berth.

Gonzaga scored first but BYU collected four runs in the sixth and four more in the?eighth.

Gonzaga got nine of??


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STOCKTON, Calif. ? The West Coast Conference regular-season champion Gonzaga Bulldogs in all likelihood saw their baseball season come to an early end as they lost their second straight game in the conference tournament on Friday?afternoon.

The top-seeded Bulldogs (32-21-1) were eliminated after falling 8-1 to No. 3 seed Brigham Young (32-20) at Banner Island?Ballpark.

With their seventh consecutive loss and an unimpressive RPI, the Bulldogs are not considered a probable candidate for an at-large NCAA tournament?berth.

Gonzaga scored first but BYU collected four runs in the sixth and four more in the?eighth.

Gonzaga got nine of its 11 hits off of BYU starter Jeff Barker (6-3), who went seven innings, walking three and striking out four. James Lengal pitched the final two scoreless?innings.

Gonzaga had its opportunities early, but couldn?t capitalize. The Bulldogs loaded the bases with one out in the third, but Barker?escaped.

The Bulldogs scored in the top of the sixth when Forbes? two-out single brought in Marco?Gonzales.

BYU responded in the bottom of the inning. Adam Law, Kelton Caldwell, Bret Lopez and Dakota Hernandez all hit RBI singles to give the Cougars a 4-1?advantage.

The Cougars added four insurance runs in the eight to cap the?scoring.

Gonzaga?s Payden Cawley Lamb went 3 for 4 from the?plate.

GU?s Tyler Olson (9-4), the WCC Pitcher of the Year, gave up six runs on 11 hits in seven innings. He struck out five and walked?two.

GU fell 8-5 to San Francisco on Thursday. The Dons beat San Diego 10-8 Friday to advance to today?s championship game, also against USD, which defeated BYU 7-4 in Friday?s late elimination game. Today?s winner gets an NCAA?berth.

Source: http://www.spokesman.com/stories/2013/may/25/byu-knocks-out-gonzaga-at-wcc-baseball-tourney/

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